BDBM50272429 2-tert-Butyl-5-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propoxy)pyrimidine::CHEMBL524826

SMILES CC(C)(C)c1ncc(OCCCc2nc(no2)-c2ccc(F)cc2Cl)cn1

InChI Key InChIKey=GASFAQIEJVLYMT-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50272429   

TargetCannabinoid receptor 2(Rat)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272429(2-tert-Butyl-5-(3-(3-(2-chloro-4-fluorophenyl)-1,2...)
Affinity DataEC50:  16nMAssay Description:Agonist activity at rat recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272429(2-tert-Butyl-5-(3-(3-(2-chloro-4-fluorophenyl)-1,2...)
Affinity DataEC50:  540nMAssay Description:Agonist activity at rat recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272429(2-tert-Butyl-5-(3-(3-(2-chloro-4-fluorophenyl)-1,2...)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272429(2-tert-Butyl-5-(3-(3-(2-chloro-4-fluorophenyl)-1,2...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272429(2-tert-Butyl-5-(3-(3-(2-chloro-4-fluorophenyl)-1,2...)
Affinity DataEC50:  610nMAssay Description:Agonist activity at human CB1 receptor expressed in Sf9 cells by GTP-europium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50272429(2-tert-Butyl-5-(3-(3-(2-chloro-4-fluorophenyl)-1,2...)
Affinity DataEC50:  4.90nMAssay Description:Agonist activity at human recombinant CB2 receptor expressed in Sf9 cells by GTP-europium binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed