BDBM50272089 CHEMBL4126331

SMILES Cc1cc(cc(C)c1C#CC(C)(C)CC(O)=O)N1CCOc2ncnc(N)c2C1=O

InChI Key InChIKey=SZHDFZYDTUBTCE-UHFFFAOYSA-N

Data  8 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50272089   

TargetCytochrome P450 1A2(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50272089(CHEMBL4126331)
Affinity DataIC50: 2.76E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50272089(CHEMBL4126331)
Affinity DataIC50: 2.72E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50272089(CHEMBL4126331)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human DGAT2 expressed in insect cell membranes using diacylglycerol/[14C]-oleoyl-CoA as substrate preincubated for 10 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50272089(CHEMBL4126331)
Affinity DataEC50:  26nMAssay Description:Inhibition of DGAT1 in human HEK293 cells using [13C18]oleic acid as substrate assessed as decrease in triacylglycerol synthesis preincubated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50272089(CHEMBL4126331)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50272089(CHEMBL4126331)
Affinity DataIC50: 2.97E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50272089(CHEMBL4126331)
Affinity DataIC50: 4.55E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50272089(CHEMBL4126331)
Affinity DataIC50: 21nMAssay Description:Inhibition of human DGAT1 expressed in insect cell membranes using diacylglycerol/[14C]-oleoyl-CoA as substrate preincubated for 10 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50272089(CHEMBL4126331)
Affinity DataIC50: 12nMAssay Description:Inhibition of mouse DGAT1 expressed in insect cell membranes using diacylglycerol/[14C]-oleoyl-CoA as substrate preincubated for 10 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed