BDBM50271830 2-Benzyl-isothiourea::CHEMBL1224309::CHEMBL505665

SMILES NC(=N)SCc1ccccc1

InChI Key InChIKey=GTRLQRHWPXEBLF-UHFFFAOYSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50271830   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50271830(CHEMBL505665 | CHEMBL1224309 | 2-Benzyl-isothioure...)
Affinity DataIC50: 6.10E+4nMAssay Description:Inhibition of IDO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50271830(CHEMBL505665 | CHEMBL1224309 | 2-Benzyl-isothioure...)
Affinity DataIC50: 6.10E+4nMAssay Description:Inhibition of indoleamine-2,3-dioxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50271830(CHEMBL505665 | CHEMBL1224309 | 2-Benzyl-isothioure...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of indoleamine-2,3-dioxygenase in human A431 cells assessed as inhibition of IFN-gamma-stimulated kynurenine productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50271830(CHEMBL505665 | CHEMBL1224309 | 2-Benzyl-isothioure...)
Affinity DataIC50: 6.10E+4nMAssay Description:Inhibition of recombinant human IDO using L-tryptophan as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50271830(CHEMBL505665 | CHEMBL1224309 | 2-Benzyl-isothioure...)
Affinity DataKi:  630nMAssay Description:Inhibition of nNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50271830(CHEMBL505665 | CHEMBL1224309 | 2-Benzyl-isothioure...)
Affinity DataKi:  5.60E+3nMAssay Description:Inhibition of iNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50271830(CHEMBL505665 | CHEMBL1224309 | 2-Benzyl-isothioure...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50271830(CHEMBL505665 | CHEMBL1224309 | 2-Benzyl-isothioure...)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition of eNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed