BDBM50271762 CHEMBL484109::N4-(3-Bromophenyl)-6-[2-(2-naphthyl)ethyl]-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine

SMILES Nc1nc(Nc2cccc(Br)c2)c2cc(CCc3ccc4ccccc4c3)[nH]c2n1

InChI Key InChIKey=MPXBINGDRCKJQG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50271762   

TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271762(N4-(3-Bromophenyl)-6-[2-(2-naphthyl)ethyl]-7Hpyrro...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of EGFR expressed in human tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271762(N4-(3-Bromophenyl)-6-[2-(2-naphthyl)ethyl]-7Hpyrro...)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of VEGFR1 expressed in human tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271762(N4-(3-Bromophenyl)-6-[2-(2-naphthyl)ethyl]-7Hpyrro...)
Affinity DataIC50: 1.68E+4nMAssay Description:Inhibition of VEGFR2 expressed in human tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271762(N4-(3-Bromophenyl)-6-[2-(2-naphthyl)ethyl]-7Hpyrro...)
Affinity DataIC50: 1.37E+4nMAssay Description:Inhibition of PDGFRbeta expressed in human tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed