BDBM50271756 CHEMBL4127319

SMILES OC(=O)c1ccc(cc1)-c1ccnc(Nc2cccc(c2)-c2ccccc2)n1

InChI Key InChIKey=UHSGKZKFUUFRPH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50271756   

TargetMitogen-activated protein kinase 8(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50271756(CHEMBL4127319)
Affinity DataIC50: 398nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
LigandPNGBDBM50271756(CHEMBL4127319)
Affinity DataIC50: 13nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Mouse)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50271756(CHEMBL4127319)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of CAMKK2 in mouse N39 cells assessed as decrease in AMPKalpha phosphorylation at T172 preincubated for 80 mins followed by inomycin addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50271756(CHEMBL4127319)
Affinity DataIC50: 398nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50271756(CHEMBL4127319)
Affinity DataIC50: 100nMAssay Description:Inhibition of full-length human GST-tagged CAMKK2 using 5FAM-AKPKGNKDYHLQTCCGSLAYRRR-amide as substrate preincubated for 30 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed