BDBM50271734 CHEMBL4128540

SMILES CC(C)c1cc(ccc1C#N)-c1ccnc2[nH]c(cc12)-c1ccc(OCCN2CCOCC2)cc1C

InChI Key InChIKey=QSTGCWGHXBTQEI-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50271734   

TargetInsulin receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50271734(CHEMBL4128540)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50271734(CHEMBL4128540)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DDR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Mouse)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50271734(CHEMBL4128540)
Affinity DataIC50: 501nMAssay Description:Inhibition of CAMKK2 in mouse N39 cells assessed as decrease in AMPKalpha phosphorylation at T172 preincubated for 80 mins followed by inomycin addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50271734(CHEMBL4128540)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50271734(CHEMBL4128540)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50271734(CHEMBL4128540)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of full-length human GST-tagged CAMKK2 using 5FAM-AKPKGNKDYHLQTCCGSLAYRRR-amide as substrate preincubated for 30 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
LigandPNGBDBM50271734(CHEMBL4128540)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of IKK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50271734(CHEMBL4128540)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed