BDBM50271727 CHEMBL3763799

SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CC(F)(F)C[C@H]1c1nc2ccc3cc(ccc3c2[nH]1)-c1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[Si](C)(C)CN1C(=O)[C@@H](NC(=O)OC)C(C)C

InChI Key InChIKey=KXZBJOSVAGHWQS-UHFFFAOYSA-N

Data  14 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50271727   

TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  9nMAssay Description:Inhibition of HCV NS5A L31V mutant in HCV genotype 1a assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  2nMAssay Description:Inhibition of HCV NS5A Y93C mutant in HCV genotype 1a assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  47nMAssay Description:Inhibition of HCV NS5A Y93H mutant in HCV genotype 1a assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  0.0200nMAssay Description:Inhibition of HCV NS5A L31V mutant in HCV genotype 1b assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  0.0100nMAssay Description:Inhibition of HCV NS5A Y93H mutant in HCV genotype 1b assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  2nMAssay Description:Inhibition of HCV NS5A Q30H mutant in HCV genotype 1a assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  0.0900nMAssay Description:Inhibition of HCV NS5A M28V mutant in HCV genotype 1a assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  0.0200nMAssay Description:Inhibition of HCV NS5A in HCV genotype 4a assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  0.200nMAssay Description:Inhibition of HCV NS5A in HCV genotype 3a assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  77nMAssay Description:Inhibition of HCV NS5A in HCV genotype 2b assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  0.00100nMAssay Description:Inhibition of HCV NS5A in HCV genotype 1b assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  0.00900nMAssay Description:Inhibition of HCV NS5A in HCV genotype 1a assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  6nMAssay Description:Inhibition of HCV NS5A Q30R mutant in HCV genotype 1a assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Merck

Curated by ChEMBL
LigandPNGBDBM50271727(CHEMBL3763799)
Affinity DataEC50:  0.00200nMAssay Description:Inhibition of HCV NS5A in HCV genotype 2a assessed as reduction in viral replication by cell based replicon assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2020
Entry Details Article
PubMed