BDBM50271601 CHEMBL4130209::US10543199, Compound 18

SMILES C[C@H]1Oc2cc(cnc2N)-c2c(CN(C)C(=O)c3ccccc13)nn(C)c2C#N

InChI Key InChIKey=AEUZLDSGYXKDAO-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50271601   

TargetALK tyrosine kinase receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM50271601(CHEMBL4130209 | US10543199, Compound 18)
Affinity DataIC50: 1nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor [L1196M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM50271601(CHEMBL4130209 | US10543199, Compound 18)
Affinity DataIC50: 5.5nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM50271601(CHEMBL4130209 | US10543199, Compound 18)
Affinity DataKi:  4nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2020
Entry Details Article
PubMed