BDBM50271205 CHEMBL4127114

SMILES FC(F)c1nc2ccccc2n1-c1nc(nc(n1)N1CCN(CC1)C(=O)CCOCCOCCOCCONC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CCOCC1

InChI Key InChIKey=XIUWBGIKSXLESW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50271205   

LigandPNGBDBM50271205(CHEMBL4127114)
Affinity DataIC50: 69nMAssay Description:Inhibition of recombinant human full length His-tagged PI3K p110alpha/p85alpha expressed in baculovirus expression system coexpressing PIK3R1 by TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2020
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50271205(CHEMBL4127114)
Affinity DataIC50: 182nMAssay Description:Inhibition of recombinant human GST-tagged MEK1 expressed in baculovirus infected Sf9 insect cells using inactive ERK2 as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50271205(CHEMBL4127114)
Affinity DataIC50: 42nMAssay Description:Inhibition of recombinant human full length His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system coexpressing PIK3R1 by TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50271205(CHEMBL4127114)
Affinity DataIC50: 2.29E+3nMAssay Description:Inhibition of recombinant human full length His-tagged PI3K p110gamma expressed in baculovirus expression system by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50271205(CHEMBL4127114)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Bioland Laboratory (Guangzhou Regenerative Medicine and Health - Guangdong Laboratory)

Curated by ChEMBL
LigandPNGBDBM50271205(CHEMBL4127114)
Affinity DataIC50: 69nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed