BDBM50271152 CHEMBL4127425

SMILES CNCCNC(=O)c1cc(C(C)Nc2cccc(F)c2)c2nc(cnc2c1)N1CCOCC1

InChI Key InChIKey=MUSGURQXGKSPBK-UHFFFAOYSA-N

Data  2 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50271152   

TargetSerine/threonine-protein kinase mTOR(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50271152(CHEMBL4127425)
Affinity DataKd:  2.34E+4nMAssay Description:Binding affinity to wild-type human MTOR (L1382 to W2549 residues) expressed in mammalian expression system by KINOMEScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50271152(CHEMBL4127425)
Affinity DataKd:  68nMAssay Description:Binding affinity to wild-type human PIK3Cdelta (R108 to Q1044 residues) expressed in mammalian expression system by KINOMEScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50271152(CHEMBL4127425)
Affinity DataKd:  832nMAssay Description:Binding affinity to wild-type human PIK3Calpha (R108 to N1068 residues) expressed in mammalian expression system by KINOMEScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50271152(CHEMBL4127425)
Affinity DataKd:  1.82E+3nMAssay Description:Binding affinity to wild-type human PIK3Cgamma (S144 to A1102 residues) expressed in mammalian expression system by KINOMEScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50271152(CHEMBL4127425)
Affinity DataIC50: 7nMAssay Description:Inhibition of PI3Kbeta in human PC3 cells assessed as reduction in AKT phosphorylation at S473 residue measured after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50271152(CHEMBL4127425)
Affinity DataIC50: 6nMAssay Description:Inhibition of PI3Kbeta in human PC3 cells assessed as reduction in AKT phosphorylation at Thr308 residue measured after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50271152(CHEMBL4127425)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to wild-type human PIK3Cbeta (P118 to S1070 residues) expressed in mammalian expression system by KINOMEScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2020
Entry Details Article
PubMed