BDBM50271083 5-(5-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl)-2-((4-(trifluoromethyl)phenyl)ethynyl)pyridine::5-(5-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl)-2-(2-(4-(trifluoromethyl)phenyl)ethynyl)pyridine::CHEMBL483894

SMILES Fc1cccc(Cl)c1-c1nc(c(Br)[nH]1)-c1ccc(nc1)C#Cc1ccc(cc1)C(F)(F)F

InChI Key InChIKey=KPXLXMUZOLULFL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50271083   

TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271083(5-(5-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol...)
Affinity DataIC50: 3.94E+3nMAssay Description:Inhibition of purified mPGES-1 (1 to 152) (unknown origin) extracted from detergent-solubilized baculovirus-infected insect Sf9 cell membranes using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271083(5-(5-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol...)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human mPGES-1 expressed in human 293E cell microsomes using PGH2 as substrate assessed as PGE2 production after 2.5 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271083(5-(5-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed