BDBM50270304 CHEMBL4077071

SMILES CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1

InChI Key InChIKey=VXLAKHWYGRKCGI-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50270304   

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50270304(CHEMBL4077071)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CDK6/Cyclin D1 using RB protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition measure after 120 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2020
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-dependent kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50270304(CHEMBL4077071)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human CDK2/Cyclin A1 using histone H1 as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition measure after 120 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50270304(CHEMBL4077071)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition measure after 120 mins by filt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50270304(CHEMBL4077071)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of human CDK4/Cyclin D1 using RB protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition measure after 120 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50270304(CHEMBL4077071)
Affinity DataIC50: 184nMAssay Description:Inhibition of CDK12/Cyclin K (unknown origin) preincubated for 10 mins followed by substrate and ATP addition measured after 200 mins by ADP-Glo lumi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50270304(CHEMBL4077071)
Affinity DataIC50: 187nMAssay Description:Inhibition of CDK13/Cyclin K (unknown origin) preincubated for 10 mins followed by substrate and ATP addition measured after 200 mins by ADP-Glo lumi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50270304(CHEMBL4077071)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK and [gamma-33P]-ATP as substrate pretreated for 20 mins followed by [gamma-33P]-ATP addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50270304(CHEMBL4077071)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human CDK2 pretreated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins in presence of 10 uM ATP by radiomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 6(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50270304(CHEMBL4077071)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CDK6 pretreated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins in presence of 10 uM ATP by radiomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50270304(CHEMBL4077071)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human FLT3-ITD mutant preincubated with enzyme for 20 mins followed by [gamma-33P]ATP addition and measured after 120 mins by filter bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50270304(CHEMBL4077071)
Affinity DataIC50: 2.06E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50270304(CHEMBL4077071)
Affinity DataIC50: 1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed