BDBM50269860 CHEMBL477531::N-(cyanomethyl)-3-(3,5-dimethylphenyl)-2-(2,2-diphenylacetamido)propanamide

SMILES Cc1cc(C)cc(CC(NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCC#N)c1

InChI Key InChIKey=UHSPVUASELRRIQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50269860   

TargetNeutrophil elastase(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269860(N-(cyanomethyl)-3-(3,5-dimethylphenyl)-2-(2,2-diph...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of neutrophil elastase activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCathepsin G(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269860(N-(cyanomethyl)-3-(3,5-dimethylphenyl)-2-(2,2-diph...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of cathepsin G activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269860(N-(cyanomethyl)-3-(3,5-dimethylphenyl)-2-(2,2-diph...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant cathepsin B after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269860(N-(cyanomethyl)-3-(3,5-dimethylphenyl)-2-(2,2-diph...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human recombinant cathepsin L after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269860(N-(cyanomethyl)-3-(3,5-dimethylphenyl)-2-(2,2-diph...)
Affinity DataIC50: 470nMAssay Description:Inhibition of human recombinant cathepsin S after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed