BDBM50269858 Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-cyclopropylcarbamoyl)-2-(2-fluoro-phenyl)-ethyl-ammonium

SMILES [NH3+][C@@H](Cc1ccccc1F)C(=O)N[C@]1(C[C@H]1c1ccccc1)C#N

InChI Key InChIKey=XIMJYDLECPMKMN-UHFFFAOYSA-O

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50269858   

TargetNeutrophil elastase(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50: 5.49E+3nMAssay Description:Inhibition of neutrophil elastase activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCathepsin G(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of cathepsin G activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetMyeloblastin(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50: 4.55E+3nMAssay Description:Inhibition of proteinase-3 activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50: 220nMAssay Description:Inhibition of human recombinant cathepsin C after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant cathepsin B after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50: 560nMAssay Description:Inhibition of human recombinant cathepsin L after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCathepsin S(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human recombinant cathepsin S after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCathepsin G(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50: 1.20E+3nMAssay Description:Blockade of cathepsin G processing in human U937 cells by densitometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50269858(Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-c...)
Affinity DataIC50: 1.90E+3nMAssay Description:Blockade of neutrophil elastase processing in human U937 cells after 7 days by fluorogenic substrate cleavage assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed