BDBM50269809 CHEMBL4077195

SMILES Fc1ccc(COc2ccc(cc2C(=O)Nc2cccnc2)C(F)(F)F)cc1

InChI Key InChIKey=UYNNRABFCDICBU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50269809   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Neurodegeneration Dpu

Curated by ChEMBL
LigandPNGBDBM50269809(CHEMBL4077195)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human LRRK2 using RLGRDKYKTLRQIRQ as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetSRSF protein kinase 3(Human)
Neurodegeneration Dpu

Curated by ChEMBL
LigandPNGBDBM50269809(CHEMBL4077195)
Affinity DataIC50: 158nMAssay Description:Inhibition of human MSSK1 GRSRSRSRSR as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Neurodegeneration Dpu

Curated by ChEMBL
LigandPNGBDBM50269809(CHEMBL4077195)
Affinity DataIC50: 20nMAssay Description:Inhibition of LRRK2 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Neurodegeneration Dpu

Curated by ChEMBL
LigandPNGBDBM50269809(CHEMBL4077195)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant 6His-Tev-tagged LRRK2 (1326 to 2527) (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotin-RLGRD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed