BDBM50269782 CHEMBL4091437

SMILES O[C@]1(CC(=O)Nc2ccc3[nH]c(=O)oc3c2)CC[C@H](Cc2ccc(OC(F)(F)F)cc2)CC1

InChI Key InChIKey=XGGIYXZDIKGFST-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50269782   

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269782(CHEMBL4091437)
Affinity DataIC50: 50nMAssay Description:Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mouse)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269782(CHEMBL4091437)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2020
Entry Details Article
PubMed