BDBM50269638 CHEMBL4066846

SMILES [H][C@]12Cc3ccc(O)cc3[C@](C)(CCN1C[C@H](O)c1ccccc1)[C@H]2C

InChI Key

Data  3 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50269638   

TargetKappa-type/Mu-type opioid receptor(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50269638(CHEMBL4066846)
Affinity DataIC50: 49nMAssay Description:Agonist activity at MOR/KOR in Dunkin-Hartley guinea pig ileum assessed as inhibition of electrically induced contractions after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50269638(CHEMBL4066846)
Affinity DataEC50:  59nMAssay Description:Agonist activity at Rluc-tagged DOR receptor (unknown origin) expressed in human SH-5YSY cells co-expressing RGFP-fused to Gbeta1 assessed as increas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50269638(CHEMBL4066846)
Affinity DataEC50:  22nMAssay Description:Agonist activity at Rluc-tagged MOR receptor (unknown origin) expressed in human SH-5YSY cells co-expressing RGFP-fused to Gbeta1 assessed as increas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50269638(CHEMBL4066846)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-DAMGO from MOR in rat brain membranes by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50269638(CHEMBL4066846)
Affinity DataKi:  7.30nMAssay Description:Displacement of [3H]-(+)-U69,593 from KOR in guinea pig brain membranes by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50269638(CHEMBL4066846)
Affinity DataKi:  9.60nMAssay Description:Displacement of [3H]-DPDPE from DOR in rat brain membranes by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMed