BDBM50269127 CHEMBL4084926

SMILES FC(F)c1cccnc1-c1cccc(c1)C(=O)Nc1cccc(c1-c1ccccn1)C(F)(F)F

InChI Key InChIKey=LEGRQHYTNOZRDA-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50269127   

TargetSodium channel protein type 9 subunit alpha(Human)
Amgen

Curated by ChEMBL

LigandBDBM50269127(CHEMBL4084926)Copy SMILESCopy InChI

Affinity DataIC50: 61nMAssay Description:Inhibition of slow inactivated human NaV1.7 expressed in HEK293 cells at -20 mV holding potential after 5 mins by IonWorks electrophysiology methodMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/9/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetSodium channel protein type 5 subunit alpha(Human)
Amgen

Curated by ChEMBL

LigandBDBM50269127(CHEMBL4084926)Copy SMILESCopy InChI

Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human NaV1.5 expressed in HEK293 cells at -50 mV holding potential after 3 to 5 mins by PatchXpress automated electrophysiology methodMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/9/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL