BDBM50269121 CHEMBL4100514

SMILES FC(F)(F)c1cccc(NC(=O)c2cccc(c2)-c2ccccn2)c1-c1cccnc1

InChI Key InChIKey=RLBBJINJWALGGU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50269121   

LigandPNGBDBM50269121(CHEMBL4100514)
Affinity DataIC50: 54nMAssay Description:Inhibition of slow inactivated human NaV1.7 expressed in HEK293 cells at -20 mV holding potential after 5 mins by IonWorks electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2020
Entry Details Article
PubMed
LigandPNGBDBM50269121(CHEMBL4100514)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of rat NaV1.7 at -125 mV holding potential yielding 20 to 50% inactivation after 3 to 5 mins by PatchXpress automated electrophysiology me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2020
Entry Details Article
PubMed
LigandPNGBDBM50269121(CHEMBL4100514)
Affinity DataIC50: 23nMAssay Description:Inhibition of slow inactivated rat NaV1.7 at -20 mV holding potential after 5 mins by IonWorks electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2020
Entry Details Article
PubMed
LigandPNGBDBM50269121(CHEMBL4100514)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human NaV1.5 expressed in HEK293 cells at -50 mV holding potential after 3 to 5 mins by PatchXpress automated electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2020
Entry Details Article
PubMed
LigandPNGBDBM50269121(CHEMBL4100514)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of human NaV1.7 expressed in HEK293 cells at -125 mV holding potential yielding 20 to 50% inactivation after 3 to 5 mins by PatchXpress au...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2020
Entry Details Article
PubMed