BDBM50268462 CHEMBL506616::c[L-Phe-D-pro-L-Phe-L-trp]

SMILES O=C1N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCC[C@H]12

InChI Key InChIKey=GIZJWWQFOGQPRY-UHFFFAOYSA-N

Data  14 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50268462   

TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataIC50: 440nMAssay Description:Antagonist activity at human cloned kappa opioid receptor assessed as inhibition of 50 nM U50488H-stimulated GTPgammaS binding by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataIC50: 47nMAssay Description:Binding affinity to KOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataIC50: 260nMAssay Description:Binding affinity to MOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataIC50: 2.60E+3nMAssay Description:Binding affinity to DOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataIC50: 260nMAssay Description:Displacement of [3H]DAMGO from mu-opioid receptor in guinea pig brain membranes after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataIC50: 47nMAssay Description:Displacement of [3H]CI-977 from kappa opioid receptor in guinea pig brain membranes after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetOpioid receptor delta 1(Guinea pig)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataIC50: 2.60E+3nMAssay Description:Displacement of [3H]DPDPE from delta-opioid receptor in guinea pig brain membranes after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataIC50: 260nMAssay Description:Binding affinity to mu opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataIC50: 47nMAssay Description:Binding affinity to kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human cloned mu opioid receptor assessed as inhibition of 100 nM loperamide-stimulated GTPgammaS binding by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataIC50: 47nMAssay Description:Displacement of [3H]Cl-977 from KOR in guinea pig brain membrane fraction after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataIC50: 260nMAssay Description:Displacement of DAGO from MOR in guinea pig brain membrane fraction after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]diprenorphine from rat KOP stably expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]diprenorphine from human cloned kappa opioid receptor by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]U69,593 from human KOR expressed in HEK293 cell membranes incubated for 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]diprenorphine from rat cloned KOR expressed in CHO cells after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataKi:  35nMAssay Description:Displacement of dynorphin A-(1-13) amide (Dyn A-(1-13) amide) from rat KOP stably expressed in CHO cell membrane incubated for 90 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataKi:  127nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in HEK293 cell membranes incubated for 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataKi:  130nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu receptor by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataKi:  451nMAssay Description:Displacement of [3H]DAMGO from rat MOP stably expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataKi:  619nMAssay Description:Displacement of [3H]DAMGO from rat cloned MOR expressed in CHO cells after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataKi:  619nMAssay Description:Displacement of [3H]DAMGO from rat MOP stably expressed in CHO cell membrane incubated for 90 mins by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataKi:  2.00E+3nMAssay Description:Displacement of [3H]diprenorphine from human cloned delta receptor by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataKi:  4.15E+3nMAssay Description:Displacement of [3H]DPDPE from mouse cloned DOR expressed in CHO cells after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataKi:  4.15E+3nMAssay Description:Displacement of [3H]DPDPE from mouse DOP stably expressed in CHO cell membrane incubated for 90 mins by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50268462(c[L-Phe-D-pro-L-Phe-L-trp] | CHEMBL506616)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]diprenorphine from human DOR expressed in HEK293 cell membranes incubated for 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed