BDBM50268422 CHEMBL502516::N-(2-((1S,2R,4R)-4-(isopropylamino)-2-((4-(methylthio)phenylsulfonyl)methyl)cyclohexylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide

SMILES CSc1ccc(cc1)S(=O)(=O)C[C@@H]1C[C@@H](CC[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)NC(C)C

InChI Key InChIKey=SERORCPZNYFBGM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50268422   

TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268422(N-(2-((1S,2R,4R)-4-(isopropylamino)-2-((4-(methylt...)
Affinity DataIC50: 2.05nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMC by millipore filter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268422(N-(2-((1S,2R,4R)-4-(isopropylamino)-2-((4-(methylt...)
Affinity DataIC50: 5.10nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268422(N-(2-((1S,2R,4R)-4-(isopropylamino)-2-((4-(methylt...)
Affinity DataIC50: 10.4nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed