BDBM50268368 CHEMBL496630::N-(2-((1S,2R,4R)-4-(methylamino)-2-((4-(methylthio)phenylsulfonyl)methyl)cyclohexylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide

SMILES CN[C@@H]1CC[C@H](NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)[C@H](CS(=O)(=O)c2ccc(SC)cc2)C1

InChI Key InChIKey=PIIMSMCFNBYVDH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50268368   

TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268368(N-(2-((1S,2R,4R)-4-(methylamino)-2-((4-(methylthio...)
Affinity DataIC50: 3.70nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMC by millipore filter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50268368(N-(2-((1S,2R,4R)-4-(methylamino)-2-((4-(methylthio...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed