BDBM50268325 (+/-)-4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)spiro[chroman-2,4'-piperidine]-1'-carboxamide::CHEMBL519149

SMILES O=C(NC1CCc2ccccc2CC1)N1CCC2(CC1)CC(=O)c1ccccc1O2

InChI Key InChIKey=FZSIIVFTLMHKAP-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50268325   

TargetSodium channel protein type 5 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268325((+/-)-4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annul...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Voltage-gated sodium channel subunit alpha Nav1.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268325((+/-)-4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annul...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268325((+/-)-4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annul...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpoxide hydrolase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268325((+/-)-4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annul...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human microsomal epoxide hydrolaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268325((+/-)-4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annul...)
Affinity DataIC50: 28nMAssay Description:Inhibition of rat soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268325((+/-)-4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annul...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268325((+/-)-4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annul...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed