BDBM50267582 (4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfonyl)piperazin-1-yl)(4-(trifluoromethyl)phenyl)methanone::CHEMBL522114

SMILES FC(F)(F)c1ccc(cc1)C(=O)N1CCN(CC1)S(=O)(=O)c1cc(cc(c1)C(F)(F)F)C1CC1

InChI Key InChIKey=KQQFZBCNXJHGCH-UHFFFAOYSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50267582   

TargetCannabinoid receptor 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267582((4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfony...)
Affinity DataIC50: 77nMAssay Description:Antagonist activity at rat recombinant CB1R expressed in CHO cells assessed as inhibition of methanandamide-stimulated cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267582((4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfony...)
Affinity DataIC50: 175nMAssay Description:Displacement of [3H]CP-55940 from rat recombinant CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267582((4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfony...)
Affinity DataIC50: 47nMAssay Description:Displacement of [3H]SR141716 from human recombinant CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267582((4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfony...)
Affinity DataIC50: 227nMAssay Description:Displacement of [3H] SR-141716 from rat recombinant CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267582((4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfony...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human recombinant CB1R expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267582((4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfony...)
Affinity DataEC50:  4.40nMAssay Description:Agonist activity at rat recombinant CB1R expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267582((4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfony...)
Affinity DataIC50: 58nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed