BDBM50266560 CHEMBL4104359::US10323016, Example 6

SMILES COc1ccc(cc1OC)N(C)c1cnc(SCc2c(F)cc(cc2F)C#CCN(C)C)n1-c1ccc(F)cc1

InChI Key InChIKey=VAEQURLTVRZWMG-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50266560   

TargetG-protein coupled bile acid receptor 1(Human)
Universite De Lille 2 Droit Et Sante

US Patent
LigandPNGBDBM50266560(US10323016, Example 6 | CHEMBL4104359)
Affinity DataEC50:  71nMAssay Description:In the following tables TGR5 activation by compounds and subsequent increase in intracellular cAMP were evaluated using a luciferase reporter gene as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetG-protein coupled bile acid receptor 1(Mouse)
Universite De Lille 2 Droit Et Sante

US Patent
LigandPNGBDBM50266560(US10323016, Example 6 | CHEMBL4104359)
Affinity DataEC50:  4nMAssay Description:In the following tables TGR5 activation by compounds and subsequent increase in intracellular cAMP were evaluated using a luciferase reporter gene as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetG-protein coupled bile acid receptor 1(Mouse)
Universite De Lille 2 Droit Et Sante

US Patent
LigandPNGBDBM50266560(US10323016, Example 6 | CHEMBL4104359)
Affinity DataEC50:  4.10nMAssay Description:Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Universite De Lille 2 Droit Et Sante

US Patent
LigandPNGBDBM50266560(US10323016, Example 6 | CHEMBL4104359)
Affinity DataEC50:  71nMAssay Description:Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2020
Entry Details Article
PubMed