BDBM50266404 CHEMBL4102153

SMILES NS(=O)(=O)Oc1ccc(cc1F)-c1ccc(s1)C(=O)c1c(F)ccc(O)c1F

InChI Key InChIKey=HWZREYUQBINYFF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50266404   

TargetSteryl-sulfatase(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50266404(CHEMBL4102153)
Affinity DataIC50: 82nMAssay Description:Inhibition of human placental microsomal STS assessed as formation of E1 preincubated for 30 mins followed by addition of E1S as substrate measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50266404(CHEMBL4102153)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of STS in human T47D cells preincubated for 1 hr followed by addition of [3H]-E1S/E1S as substrate measured after 24 hrs by HPLC based rad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50266404(CHEMBL4102153)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human placental cytosolic 17beta-HSD1 using [3H]-E1/E1 substrate and NADH after 10 mins by HPLC based radio-detection methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50266404(CHEMBL4102153)
Affinity DataIC50: 20nMAssay Description:Inhibition of 17beta-HSD1 in human T47D cells preincubated for 1 hr followed by addition of [3H]-E1/E1 as substrate measured after 30 mins by HPLC ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details Article
PubMed
TargetSteryl-sulfatase(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50266404(CHEMBL4102153)
Affinity DataIC50: 5.70nMAssay Description:Irreversible inhibition of STS in human T47D cells preincubated for 2 hrs followed by compound washout and addition of [3H]-E1S/E1S as substrate meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50266404(CHEMBL4102153)
Affinity DataIC50: 14nMAssay Description:Inhibition of human placental cytosolic 17beta-HSD2 using [3H]-E2/E2 substrate and NAD+ after 20 mins by HPLC based radio-detection methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details Article
PubMed