BDBM50266099 (+/-)-methyl 2-(N-(1,4-dioxaspiro[4.5]decan-8-yl)benzo[b]thiophene-3-carboxamido)-3-(4-chlorophenyl)propanoate::CHEMBL514872

SMILES COC(=O)C(Cc1ccc(Cl)cc1)N(C1CCC2(CC1)OCCO2)C(=O)c1csc2ccccc12

InChI Key InChIKey=KIAVXLCRALURJT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50266099   

LigandPNGBDBM50266099((+/-)-methyl 2-(N-(1,4-dioxaspiro[4.5]decan-8-yl)b...)
Affinity DataIC50: 172nMAssay Description:Antagonist activity at C5a receptor assessed as inhibition of C5a-induced elastase release in human neutrophils during degranulation preincubated 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266099((+/-)-methyl 2-(N-(1,4-dioxaspiro[4.5]decan-8-yl)b...)
Affinity DataIC50: 15nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed