BDBM50266003 CHEMBL4091152

SMILES C[C@H](c1ccccn1)Oc2cc3c(cc2Cl)c(no3)CCC(=O)O

InChI Key InChIKey=WPAHVUADNLXSOM-UHFFFAOYSA-N

Data  2 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50266003   

TargetKynurenine 3-monooxygenase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50266003(CHEMBL4091152)
Affinity DataIC50: 10nMAssay Description:Inhibition of KMO in human primary hepatocytes using kynurenine as substrate measured after overnight incubation by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2020
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50266003(CHEMBL4091152)
Affinity DataIC50: 5nMAssay Description:Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2020
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50266003(CHEMBL4091152)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of full length human KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2020
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50266003(CHEMBL4091152)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of KMO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50266003(CHEMBL4091152)
Affinity DataKi:  0.0500nMAssay Description:Competitive inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2020
Entry Details Article
PubMed
TargetKynurenine 3-monooxygenase(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50266003(CHEMBL4091152)
Affinity DataKi:  45nMAssay Description:Inhibition of rat KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2020
Entry Details Article
PubMed