BDBM50265784 (S)-2-(3-((S)-5-Amino-1-carboxypentyl)ureido)pentanedioic Acid::CHEMBL458202

SMILES NCCCC[C@H](NC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O

InChI Key InChIKey=ZZASEPMMGWJWOV-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50265784   

TargetGlutamate carboxypeptidase 2(Human)
National and Kapodistrian University of Athens (NKUA)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265784BDBM50265784((S)-2-(3-((S)-5-Amino-1-carboxypentyl)ureido)penta...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetGlutamate carboxypeptidase 2(Human)
National and Kapodistrian University of Athens (NKUA)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265784BDBM50265784((S)-2-(3-((S)-5-Amino-1-carboxypentyl)ureido)penta...)
Affinity DataKi:  44nMAssay Description:Inhibition of human recombinant N-terminal Avi-tagged glutamate carboxypeptidase 2 extracellular domain (44 to 750 amino acids) using pteroyl-di-L-gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
National and Kapodistrian University of Athens (NKUA)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265784BDBM50265784((S)-2-(3-((S)-5-Amino-1-carboxypentyl)ureido)penta...)
Affinity DataIC50: 498nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
National and Kapodistrian University of Athens (NKUA)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265784BDBM50265784((S)-2-(3-((S)-5-Amino-1-carboxypentyl)ureido)penta...)
Affinity DataIC50: 547nMAssay Description:Inhibition of PSMA derived from human LNCaP cell lysate assessed as inhibition of NAAG hydrolysis incubated for 2 hrs in presence of NAAG by Amplex R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGlutamate carboxypeptidase 2(Human)
National and Kapodistrian University of Athens (NKUA)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265784BDBM50265784((S)-2-(3-((S)-5-Amino-1-carboxypentyl)ureido)penta...)
Affinity DataIC50: 547nMAssay Description:Inhibition of PSMA in human LNCaP cell extracts using NAAG as substrate by amplex red reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate carboxypeptidase 2(Human)
National and Kapodistrian University of Athens (NKUA)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265784BDBM50265784((S)-2-(3-((S)-5-Amino-1-carboxypentyl)ureido)penta...)
Affinity DataIC50: 547nMAssay Description:Inhibition of GCPII (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetGlutamate carboxypeptidase 2(Human)
National and Kapodistrian University of Athens (NKUA)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265784BDBM50265784((S)-2-(3-((S)-5-Amino-1-carboxypentyl)ureido)penta...)
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibition of PSMA in human LNCAP cells using NAAG as substrate measured after 2 hrs by amplex red reagent based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed