BDBM50265501 (R)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluoromethyl)phenylsulfonamido)piperidine-1-carbonyl)pyrrolidine-1-carboxylate::CHEMBL372397::tert-Butyl (2R)-2-{[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl}amino)piperidin-1-yl]carbonyl}pyrrolidine-1-carboxylate

SMILES CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1

InChI Key InChIKey=FCXCNDHEICKHMB-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50265501   

TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265501(tert-Butyl (2R)-2-{[4-({[5-(Phenylsulfonyl)-2-(tri...)
Affinity DataEC50:  210nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265501(tert-Butyl (2R)-2-{[4-({[5-(Phenylsulfonyl)-2-(tri...)
Affinity DataIC50: 120nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265501(tert-Butyl (2R)-2-{[4-({[5-(Phenylsulfonyl)-2-(tri...)
Affinity DataEC50:  210nMAssay Description:Inhibition of human recombinant SFRP1 expressed in human U2OS cells assessed as increase in Wnt signaling after 16 to 18 hrs by luciferase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265501(tert-Butyl (2R)-2-{[4-({[5-(Phenylsulfonyl)-2-(tri...)
Affinity DataIC50: 120nMAssay Description:Displacement of fluorescence probe compound from human SFRP1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed