BDBM50264811 CHEMBL485492::N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl)acetamide::US10357546, ND-364

SMILES CC(=O)Nc1ccc(Oc2ccc(cc2)S(=O)(=O)CC2CS2)cc1

InChI Key InChIKey=QNKSDDQPRLWOEC-UHFFFAOYSA-N

Data  21 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50264811   

Target72 kDa type IV collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataIC50: 170nMAssay Description:Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to testing measured for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataIC50: 529nMAssay Description:Inhibition of human full length MMP9 using Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to testing measured for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  110nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  130nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  130nMAssay Description:Inhibition of human recombinant MMP9 assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  130nMAssay Description:Inhibition of human recombinant MMP9 catalytic domain assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
University of Notre Dame Du Lac

US Patent
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  130nMAssay Description:Human recombinant active MMP-2 and MMP-7, and the catalytic domains of MMP-3 and MMP-14/MT1-MMP were purchased from EMD Chemicals, Inc. (San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetMatrix metalloproteinase-14(Human)
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  680nMAssay Description:Inhibition of human recombinant MMP14 assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  680nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  840nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  3.40E+3nMAssay Description:Human recombinant active MMP-2 and MMP-7, and the catalytic domains of MMP-3 and MMP-14/MT1-MMP were purchased from EMD Chemicals, Inc. (San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetInterstitial collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  5.40E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  5.40E+3nMAssay Description:Inhibition of human recombinant MMP1 assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  1.22E+4nMAssay Description:Inhibition of human recombinant MMP3 assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  1.22E+4nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  3.40E+4nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMatrilysin(Human)
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  3.90E+4nMAssay Description:Inhibition of human recombinant MMP7 assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMatrilysin(Human)
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  3.90E+4nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi: >2.30E+5nMAssay Description:Inhibition of MMP-14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMatrilysin(Human)
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi: >1.84E+5nMAssay Description:Inhibition of MMP-7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetStromelysin-1(Human)
University of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi: >1.88E+5nMAssay Description:Inhibition of MMP-3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetInterstitial collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi: >1.54E+5nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50264811(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  1.10E+5nMAssay Description:Inhibition of human recombinant MMP2 assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed