BDBM50264742 2-(2H-tetrazol-5-yl)-4-(4'-(trifluoromethyl)biphenyl-4-yloxy)thieno[2,3-c]pyridine::CHEMBL490423

SMILES FC(F)(F)c1ccc(cc1)-c1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1

InChI Key InChIKey=BWURVMSADXYTFO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50264742   

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264742(2-(2H-tetrazol-5-yl)-4-(4'-(trifluoromethyl)biphen...)
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264742(2-(2H-tetrazol-5-yl)-4-(4'-(trifluoromethyl)biphen...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of MEK1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264742(2-(2H-tetrazol-5-yl)-4-(4'-(trifluoromethyl)biphen...)
Affinity DataIC50: 560nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed