BDBM50264576 7-(5-(3-hydroxypropoxy)-1H-indol-2-yl)isoindolin-1-one::CHEMBL449663

SMILES OCCCOc1ccc2[nH]c(cc2c1)-c1cccc2CNC(=O)c12

InChI Key InChIKey=IOCFSLNXNXVRSR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50264576   

TargetVascular endothelial growth factor receptor 2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50264576(7-(5-(3-hydroxypropoxy)-1H-indol-2-yl)isoindolin-1...)
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50264576(7-(5-(3-hydroxypropoxy)-1H-indol-2-yl)isoindolin-1...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50264576(7-(5-(3-hydroxypropoxy)-1H-indol-2-yl)isoindolin-1...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed