BDBM50264503 CHEMBL4100994

SMILES Cc1cnc2c(S)cccc2c1

InChI Key InChIKey=VALHNLZUZSNADP-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50264503   

TargetCOP9 signalosome complex subunit 5(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264503(CHEMBL4100994)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
Target26S proteasome non-ATPase regulatory subunit 14(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264503(CHEMBL4100994)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264503(CHEMBL4100994)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of recombinant human MMP2 catalytic domain (Tyr110 to Asp452 residues) expressed in yeast using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264503(CHEMBL4100994)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of full length recombinant human C-terminal His/FLAG-tagged HDAC1 expressed in baculovirus expression system using substrate 3 preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264503(CHEMBL4100994)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of recombinant human 5-LO expressed in baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264503(CHEMBL4100994)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus expression system using substrate 3 preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264503(CHEMBL4100994)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human carbonic anhydrase-2 using p-nitrophenylacetate as substrate preincubated for 10 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed