BDBM50263669 (1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetrahydrocyclopropa[b]chromene-1a-carboxamide

SMILES O=NC1[C@@H]2C[C@@]2(Oc2ccccc12)C(=O)Nc1ccccc1

InChI Key InChIKey=UUGZPCXLWMAKDE-UHFFFAOYSA-N

Data  1 IC50  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50263669   

TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50263669((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Affinity DataIC50: 3.00E+3nMAssay Description:Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50263669((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human mGluR4 receptor expressed in CHO cells assessed as effect on calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50263669((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Affinity DataEC50:  2.03E+3nMAssay Description:Activity at rat mGluR4 receptor expressed in HEK293 cells assessed as effect on thallium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50263669((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Affinity DataEC50:  5.00E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50263669((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Affinity DataEC50:  3.10E+3nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50263669((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Affinity DataEC50:  4.10E+3nMAssay Description:Activity at human mGluR4 expressed in CHO coexpressing Gqi5 assessed as potentiation of glutamate-induced calcium flux by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50263669((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Affinity DataEC50:  4.74E+3nMAssay Description:Positive allosteric modulation of human mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50263669((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Affinity DataEC50:  2.82E+3nMAssay Description:Positive allosteric modulation of rat mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed