BDBM50263547 CHEMBL4077957::US11236046, Example 41

SMILES C[C@H]1CC[C@H](N1S(=O)(=O)c1ccc(F)cc1)C(=O)NCc1cc(ncn1)-c1ccc(nc1)C(F)(F)F

InChI Key InChIKey=BBCFRTHODCIVDP-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50263547   

TargetTransient receptor potential cation channel subfamily A member 1(Human)
Pharmaron-Beijing

Curated by ChEMBL

LigandBDBM50263547(CHEMBL4077957 | US11236046, Example 41)Copy SMILESCopy InChI

Affinity DataIC50: 13nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/31/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetTransient receptor potential cation channel subfamily A member 1(Human)
Pharmaron-Beijing

Curated by ChEMBL

LigandBDBM50263547(CHEMBL4077957 | US11236046, Example 41)Copy SMILESCopy InChI

Affinity DataIC50: 5nMAssay Description:IC50s (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/6/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL