BDBM50263521 CHEMBL4080418::US11236046, Example 201

SMILES Fc1ccc(cc1)S(=O)(=O)N1CC[C@H]1C(=O)NCc1cc(ncn1)-c1ccc(nc1)C(F)(F)F

InChI Key InChIKey=ZPQGIOXLLCZONP-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50263521   

TargetTransient receptor potential cation channel subfamily A member 1(Human)
Pharmaron-Beijing

Curated by ChEMBL

LigandBDBM50263521(CHEMBL4080418 | US11236046, Example 201)Copy SMILESCopy InChI

Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/31/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetTransient receptor potential cation channel subfamily A member 1(Human)
Pharmaron-Beijing

Curated by ChEMBL

LigandBDBM50263521(CHEMBL4080418 | US11236046, Example 201)Copy SMILESCopy InChI

Affinity DataIC50: 268nMAssay Description:IC50s (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/6/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL