BDBM50263382 CHEMBL4065418

SMILES CC(C)C[C@@H]1N[C@H]2CSSC[C@H]3NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc4ccccc4)C(=O)NC2=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC3=O)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC1=O)[C@@H](C)O)[C@@H](C)O

InChI Key InChIKey=UMNQTBNJKUNGLZ-UHFFFAOYSA-N

Data  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50263382   

TargetMelanocyte-stimulating hormone receptor(Mouse)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50263382(CHEMBL4065418)
Affinity DataEC50:  1.10E+4nMAssay Description:Agonist activity at mouse MC1R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Mouse)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50263382(CHEMBL4065418)
Affinity DataEC50:  1.40E+4nMAssay Description:Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Mouse)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50263382(CHEMBL4065418)
Affinity DataEC50:  5.20E+3nMAssay Description:Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50263382(CHEMBL4065418)
Affinity DataEC50:  1.40E+3nMAssay Description:Displacement of Eu-NDP-MSH from human MC1R expressed in HEK293T cells after 2 hrs by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50263382(CHEMBL4065418)
Affinity DataEC50:  2.20E+4nMAssay Description:Agonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50263382(CHEMBL4065418)
Affinity DataEC50:  3.80E+3nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50263382(CHEMBL4065418)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed