BDBM50263381 CHEMBL4097903

SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2[C@H]2CSSC[C@H](NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](Cc4ccccc4)NC1=O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NC2=O)C(=O)N[C@@H](CCCCN)C(N)=O

InChI Key InChIKey=CFQRWRHLWMZZET-UHFFFAOYSA-N

Data  1 KI  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50263381   

TargetMelanocortin receptor 4(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50263381(CHEMBL4097903)
Affinity DataEC50:  2.10E+4nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50263381(CHEMBL4097903)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human MC5R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50263381(CHEMBL4097903)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human MC3R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50263381(CHEMBL4097903)
Affinity DataIC50: 2.60E+4nMAssay Description:Displacement of [125I]-NDP-MSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50263381(CHEMBL4097903)
Affinity DataEC50:  7.40E+3nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM50263381(CHEMBL4097903)
Affinity DataKi:  30nMAssay Description:Displacement of Eu-NDP-MSH from human MC1R expressed in HEK293T cells after 2 hrs by DELFIA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed