BDBM50263324 CHEMBL513893::trans-5'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'-isobenzofuran]-4-carboxylic acid methyl-(2-piperidin-1-yl-ethyl)-amide

SMILES COc1ccc2c(c1)C(=O)O[C@]21CC[C@@H](CC1)C(=O)N(C)CCN1CCCCC1

InChI Key InChIKey=AEWLECDUIOHVBW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50263324   

TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263324(trans-5'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'...)
Affinity DataIC50: 0.540nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263324(trans-5'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-6-yl]meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263324(trans-5'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263324(trans-5'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263324(trans-5'-Methoxy-3'-oxo-3'H-spiro[cyclohexane-1,1'...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed