BDBM50263059 CHEMBL4105556

SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Nc2ccc(NC(=O)C3CC3)cc2)n1

InChI Key InChIKey=FXGOMJXGESCWPD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50263059   

TargetAurora kinase B(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263059(CHEMBL4105556)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of human recombinant AurKB after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263059(CHEMBL4105556)
Affinity DataIC50: 178nMAssay Description:Inhibition of human recombinant RIPK1 after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263059(CHEMBL4105556)
Affinity DataIC50: 293nMAssay Description:Inhibition of human recombinant AurKA after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Mouse)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263059(CHEMBL4105556)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Mouse)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263059(CHEMBL4105556)
Affinity DataIC50: 640nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed