BDBM50263046 CHEMBL4069729

SMILES Cc1cc(Nc2cc(nc(Nc3ccc(NC(=O)C4CC4)cc3)n2)N2CCCCC2)n[nH]1

InChI Key InChIKey=JNZKENWWCGIHDV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50263046   

TargetAurora kinase A(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263046(CHEMBL4069729)
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant AurKA after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263046(CHEMBL4069729)
Affinity DataIC50: 959nMAssay Description:Inhibition of human recombinant AurKB after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263046(CHEMBL4069729)
Affinity DataIC50: 295nMAssay Description:Inhibition of human recombinant RIPK1 after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Mouse)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263046(CHEMBL4069729)
Affinity DataIC50: 680nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Mouse)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263046(CHEMBL4069729)
Affinity DataIC50: 530nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263046(CHEMBL4069729)
Affinity DataIC50: 295nMAssay Description:Inhibition of recombinant human RIP1 incubated for 4 hrs by ADP-Glo reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed