BDBM50263008 CHEMBL255473

SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

InChI Key InChIKey=JTVCWQUNPMKMER-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50263008   

TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50263008(CHEMBL255473)
Affinity DataIC50: 6nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50263008(CHEMBL255473)
Affinity DataIC50: 2.06E+3nMAssay Description:Displacement of [3H]IN973 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50263008(CHEMBL255473)
Affinity DataIC50: 8.70nMAssay Description:Displacement of [3H]L685458 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed