BDBM50262806 -Diamino-5-isopropyl-6-(2'-naphthylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine::CHEMBL477150

SMILES CC(C)c1c(Sc2ccc3ccccc3c2)[nH]c2nc(N)nc(N)c12

InChI Key InChIKey=FVTLWDMKFHXFCR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50262806   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262806(-Diamino-5-isopropyl-6-(2'-naphthylsulfanyl)-7H-py...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of Toxoplasma gondii thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262806(-Diamino-5-isopropyl-6-(2'-naphthylsulfanyl)-7H-py...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262806(-Diamino-5-isopropyl-6-(2'-naphthylsulfanyl)-7H-py...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of Escherichia coli thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262806(-Diamino-5-isopropyl-6-(2'-naphthylsulfanyl)-7H-py...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of human thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262806(-Diamino-5-isopropyl-6-(2'-naphthylsulfanyl)-7H-py...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of rat liver DHFR using dihydrofolic acid substrate and NADPH cofactorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262806(-Diamino-5-isopropyl-6-(2'-naphthylsulfanyl)-7H-py...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed