BDBM50262599 2,4-Diamino-5-propyl-6-(phenylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine::CHEMBL516891

SMILES CCCc1c(Sc2ccccc2)[nH]c2nc(N)nc(N)c12

InChI Key InChIKey=KSJUTZNJZBBMIQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50262599   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262599(2,4-Diamino-5-propyl-6-(phenylsulfanyl)-7H-pyrrolo...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of Toxoplasma gondii thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262599(2,4-Diamino-5-propyl-6-(phenylsulfanyl)-7H-pyrrolo...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262599(2,4-Diamino-5-propyl-6-(phenylsulfanyl)-7H-pyrrolo...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262599(2,4-Diamino-5-propyl-6-(phenylsulfanyl)-7H-pyrrolo...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of Escherichia coli thymidylate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262599(2,4-Diamino-5-propyl-6-(phenylsulfanyl)-7H-pyrrolo...)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of rat liver DHFR using dihydrofolic acid substrate and NADPH cofactorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50262599(2,4-Diamino-5-propyl-6-(phenylsulfanyl)-7H-pyrrolo...)
Affinity DataIC50: 120nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed