BDBM50262463 (S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-7,7-dimethyl-5,6,7,8-tetrahydrothiazolo[5,4-c]azepin-4-one::CHEMBL514869

SMILES CC1(C)CNC(=O)c2sc(nc2C1)N1CCOC[C@@H]1Cc1c[nH]c2ccccc12

InChI Key InChIKey=ZCCMLCRXWWFYEG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50262463   

LigandPNGBDBM50262463((S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-7,7-di...)
Affinity DataIC50: 59nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262463((S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-7,7-di...)
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262463((S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-7,7-di...)
Affinity DataIC50: 18nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262463((S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-7,7-di...)
Affinity DataIC50: 31nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262463((S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-7,7-di...)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of PI3K-mediated AKT Ser473 phosphorylation in PTEN negative human PC3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262463((S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-7,7-di...)
Affinity DataIC50: 199nMAssay Description:Inhibition of PI3K-mediated AKT Ser473 phosphorylation in PTEN negative human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed