BDBM50262402 CHEMBL4060267

SMILES Cc1c(-c2ccc(cc2)N2CCNCC2)n(C)c2nc(cc(Cl)c12)C(N)=O

InChI Key InChIKey=ZMKZZRCGXNIFIA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50262402   

TargetSerine/threonine-protein kinase pim-1(Human)
Sanofi Genzyme

Curated by ChEMBL
LigandPNGBDBM50262402(CHEMBL4060267)
Affinity DataIC50: 43nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in full length human BAD phosphorylation at Ser112 residues by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Sanofi Genzyme

Curated by ChEMBL
LigandPNGBDBM50262402(CHEMBL4060267)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of PIM2 (unknown origin) assessed as reduction in full length human BAD phosphorylation at Ser112 residues by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
Sanofi Genzyme

Curated by ChEMBL
LigandPNGBDBM50262402(CHEMBL4060267)
Affinity DataIC50: 290nMAssay Description:Inhibition of PIM3 (unknown origin) assessed as reduction in full length human BAD phosphorylation at Ser112 residues by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2020
Entry Details Article
PubMed