BDBM50261857 CHEMBL4082422

SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n(C3CCCNC3)c2n1

InChI Key InChIKey=DAGZBPRGFBEYDJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50261857   

TargetSerine/threonine-protein kinase pim-2(Human)
Sanofi Genzyme

Curated by ChEMBL
LigandPNGBDBM50261857(CHEMBL4082422)
Affinity DataIC50: 13nMAssay Description:Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Sanofi Genzyme

Curated by ChEMBL
LigandPNGBDBM50261857(CHEMBL4082422)
Affinity DataIC50: 115nMAssay Description:Inhibition of PIM1 in human KG1 cells assessed as reduction in BAD phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50261857(CHEMBL4082422)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Sanofi Genzyme

Curated by ChEMBL
LigandPNGBDBM50261857(CHEMBL4082422)
Affinity DataIC50: 1nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2020
Entry Details Article
PubMed