BDBM50261325 CHEMBL4060556

SMILES Fc1ccc(nc1)-c1nc2CN(CCc2o1)C(=O)c1ccccc1

InChI Key InChIKey=FOPJMYBQTFPHTL-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50261325   

TargetCytochrome P450 1A2(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261325(CHEMBL4060556)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261325(CHEMBL4060556)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261325(CHEMBL4060556)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261325(CHEMBL4060556)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261325(CHEMBL4060556)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261325(CHEMBL4060556)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261325(CHEMBL4060556)
Affinity DataIC50: 54nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261325(CHEMBL4060556)
Affinity DataIC50: 6.40E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261325(CHEMBL4060556)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed