BDBM50261324 CHEMBL4098822

SMILES Fc1ccc(nc1)-c1cc2CN(CCn2n1)C(=O)c1cc(F)cc(Cl)c1

InChI Key InChIKey=PAVOURBCAONWKJ-UHFFFAOYSA-N

Data  26 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50261324   

TargetCytochrome P450 2C9(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 10 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 10 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 10 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 10 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 10 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 75nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as L-glutamate-induced intracellular calcium mobilizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate after 10 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 10 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 10 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 75nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells assessed as L-glutamate-induced intracellular calcium mobilizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate after 10 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 10 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquin as substrate after 10 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquin as substrate after 10 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sumitomo Dainippon Pharma

Curated by ChEMBL
LigandPNGBDBM50261324(CHEMBL4098822)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2020
Entry Details Article
PubMed